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Today's college football lineup brings excitement with 16 of the top 25 teams in action. Check out the full schedule below with odds & picks. Week 10 promises key matchups, including two top-10 teams facing tough road games.

One of those challenges is for No. 4 Ohio State, heading to Beaver Stadium to face No. 3 Penn State in a high-stakes, top-five showdown at 12 p.m. ET on Fox's Big Noon Kickoff. Later in prime time, No. 10 Texas A&M takes on South Carolina at 7:30 p.m. ET on ABC, adding more drama to the evening slate.


Since 2021, Penn State has struggled against elite Big Ten teams, going 0-6 against Ohio State and Michigan, while boasting a strong 35-5 record against other opponents. Ohio State has dominated their recent meetings with Penn State, winning seven in a row and 11 of the last 12 matchups, each victory coming by a margin of 8 to 13 points.

Following a loss to Oregon, Ohio State urgently needs this win to stay in the College Football Playoff race. With a talent edge, Ryan Day's squad is set to continue their winning streak against the Nittany Lions. Take Ohio State ATS

Picks NCAAF
Spread
Money
Total
11 picks 8:00 PM
7.5 -110
249
O57.5 -115
-7.5 -110
-300
U57.5 -105
7 picks 8:00 PM
-1.5 -110
-115
O62.5 -110
1.5 -110
-105
U62.5 -110
Picks NCAAF
Spread
Money
Total
1 picks 9:00 PM
-6.0 -110
-238
O45.0 -110
6.0 -110
197
U45.0 -110
2 picks 10:30 PM
2.5 -110
115
O66.0 -108
-2.5 -110
-135
U66.0 -112
Picks NCAAF
Spread
Money
Total
2 picks 12:00 PM
21.5 -110
875
O48.0 -105
-21.5 -110
-1721
U48.0 -115
1 picks 12:00 PM
5.0 -113
170
O56.5 -110
-5.0 -107
-195
U56.5 -110
2 picks 12:00 PM
-3.0 -104
-148
O57.5 -110
3.0 -116
127
U57.5 -110
2 picks 12:00 PM
-7.5 -106
-274
O49.0 -110
7.5 -114
223
U49.0 -110
2 picks 12:00 PM
-2.5 -115
-138
O55.0 -105
2.5 -106
118
U55.0 -115
1 picks 2:30 PM
-6.5 -110
-239
O56.5 -109
UAB
6.5 -110
198
U56.5 -111
1 picks 3:00 PM
-13.5 -110
-543
O55.0 -110
13.5 -110
400
U55.0 -110
2 picks 3:30 PM
-3.0 -108
-145
O50.0 -110
3.0 -112
125
U50.0 -110
1 picks 3:30 PM
-5.5 -110
-210
O63.5 -110
5.5 -110
180
U63.5 -110
5 picks 3:30 PM
14.0 -106
461
O49.5 -110
-14.0 -114
-622
U49.5 -110
2 picks 4:00 PM
-3.5 -105
-165
O62.5 -110
3.5 -115
145
U62.5 -110
1 picks 6:00 PM
-18.0 -110
-1000
O52.0 -110
18.0 -110
633
U52.0 -110
1 picks 7:00 PM
3.0 -117
130
O55.5 -110
-3.0 -106
-150
U55.5 -110
1 picks 7:00 PM
24.5 -110
1190
O57.5 -110
-24.5 -110
-3231
U57.5 -110
1 picks 7:00 PM
11.0 -110
345
O66.5 -110
TCU
-11.0 -110
-442
U66.5 -110
1 picks 7:00 PM
24.0 -113
1170
O61.0 -110
-24.0 -107
-2800
U61.0 -110
2 picks 7:00 PM
-3.0 -107
-144
O58.0 -110
LSU
3.0 -113
123
U58.0 -110
1 picks 8:00 PM
24.0 -110
1175
O60.5 -110
-24.0 -110
-3143
U60.5 -110
1 picks 9:00 PM
-12.5 -110
-465
O49.5 -110
12.5 -110
364
U49.5 -110